| MPM BIOIMPACT LLC | 9,731,341 | $177.2m | 10.8% |
| Lynx1 Capital Management LP | 8,963,500 | $163.2m | 18.9% |
| BVF INC/IL | 5,750,683 | $104.7m | 2.7% |
| BlackRock, Inc. | 5,232,766 | $95.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,825,950 | $69.7m | 0.0% |
| STATE STREET CORP | 3,668,627 | $66.8m | 0.0% |
| Kynam Capital Management, LP | 3,114,132 | $56.7m | 3.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,614,066 | $47.6m | 0.0% |
| RTW INVESTMENTS, LP | 2,364,347 | $43.1m | 0.4% |
| Siren, L.L.C. | 1,893,410 | $34.5m | 0.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,547,309 | $28.2m | 0.0% |
| Blue Owl Capital Holdings LP | 1,539,764 | $28.0m | 4.2% |
| Venrock Adviser, LLC | 1,379,965 | $25.1m | 0.8% |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,082,611 | $19.7m | 0.3% |
| DIMENSIONAL FUND ADVISORS LP | 1,046,694 | $19.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,001,598 | $18.2m | 0.0% |
| Affinity Asset Advisors, LLC | 875,760 | $15.9m | 0.7% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 738,741 | $13.5m | 0.0% |
| BOONE CAPITAL MANAGEMENT LLC | 704,442 | $12.8m | 3.0% |
| Elmind Capital, LP | 690,000 | $12.6m | 3.2% |
| MORGAN STANLEY | 629,035 | $11.5m | 0.0% |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | $10.8m | 1.1% |
| AQR CAPITAL MANAGEMENT LLC | 581,338 | $10.6m | 0.0% |
| NORTHERN TRUST CORP | 571,080 | $10.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 510,325 | $9.3m | 0.0% |