| RA CAPITAL MANAGEMENT, L.P. | 11,300,939 | $147.4m | 1.3% |
| FMR LLC | 6,790,364 | $88.5m | 0.0% |
| UBS Group AG | 3,404,866 | $44.4m | 0.0% |
| BRAIDWELL LP | 2,797,375 | $36.5m | 1.3% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,506,000 | $32.7m | 0.0% |
| BlackRock, Inc. | 2,354,872 | $30.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,127,281 | $27.7m | 0.0% |
| Cormorant Asset Management, LP | 2,106,000 | $27.5m | 1.4% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,939,019 | $25.3m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,698,654 | $22.2m | 0.0% |
| Woodline Partners LP | 1,582,291 | $20.6m | 0.1% |
| CITADEL ADVISORS LLC | 1,297,972 | $16.9m | 0.0% |
| Redmile Group, LLC | 1,226,330 | $16.0m | 1.1% |
| GREAT POINT PARTNERS LLC | 1,000,000 | $13.0m | 2.5% |
| Affinity Asset Advisors, LLC | 972,000 | $12.7m | 0.6% |
| MILLENNIUM MANAGEMENT LLC | 908,198 | $11.8m | 0.0% |
| ADAR1 Capital Management, LLC | 822,649 | $10.7m | 0.5% |
| Driehaus Capital Management LLC | 790,000 | $10.3m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 782,199 | $10.2m | 0.0% |
| STEMPOINT CAPITAL LP | 742,745 | $9.7m | 1.7% |
| STATE STREET CORP | 686,772 | $9.0m | 0.0% |
| AMERIPRISE FINANCIAL INC | 657,971 | $8.6m | 0.0% |
| Parkman Healthcare Partners LLC | 563,484 | $7.3m | 0.8% |
| SUPERSTRING CAPITAL MANAGEMENT LP | 521,082 | $6.8m | 4.3% |
| SPHERA FUNDS MANAGEMENT LTD. | 483,747 | $6.3m | 0.8% |