| TANG CAPITAL MANAGEMENT LLC | 17,990,782 | $39.4m | 1.8% |
| ORBIMED ADVISORS LLC | 15,219,994 | $33.3m | 0.6% |
| MONTANOVA CAPITAL, LLC | 14,101,159 | $30.9m | 0.6% |
| BlackRock, Inc. | 11,281,781 | $24.7m | 0.0% |
| STATE STREET CORP | 9,953,653 | $21.8m | 0.0% |
| ENAVATE SCIENCES GP, LLC | 7,788,150 | $17.1m | 4.9% |
| Vivo Capital, LLC | 7,757,060 | $17.0m | 1.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,118,782 | $13.4m | 0.0% |
| Palo Alto Investors LP | 5,831,813 | $12.8m | 1.8% |
| MILLENNIUM MANAGEMENT LLC | 4,713,247 | $10.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,815,189 | $8.4m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,771,032 | $8.3m | 0.0% |
| Qube Research & Technologies Ltd | 3,687,489 | $8.1m | 0.0% |
| Blue Owl Capital Holdings LP | 3,624,076 | $7.9m | 1.2% |
| CITADEL ADVISORS LLC | 3,570,674 | $7.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 3,531,000 | $7.7m | 0.0% |
| Rock Springs Capital Management LP | 3,524,929 | $7.7m | 0.4% |
| AQR CAPITAL MANAGEMENT LLC | 3,509,137 | $7.7m | 0.0% |
| Birchview Capital, LP | 1,675,000 | $3.7m | 1.7% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,400,000 | $3.1m | 0.3% |
| Fisher Asset Management, LLC | 1,391,890 | $3.0m | 0.0% |
| ROYCE & ASSOCIATES LP | 1,336,780 | $2.9m | 0.0% |
| FMR LLC | 1,212,196 | $2.7m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,186,500 | $2.6m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,161,231 | $2.5m | 0.0% |