| BlackRock, Inc. | 12,432,023 | $1.1bn | 0.0% |
| INGALLS & SNYDER LLC | 7,934,507 | $689.9m | 18.8% |
| RENAISSANCE TECHNOLOGIES LLC | 5,261,628 | $457.5m | 0.6% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 5,044,638 | $438.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,172,482 | $362.8m | 0.0% |
| Parallel Advisors, LLC | 3,962,177 | $344.5m | 5.3% |
| FMR LLC | 3,337,618 | $290.2m | 0.0% |
| STATE STREET CORP | 3,279,381 | $285.2m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 2,582,561 | $224.6m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,532,198 | $220.2m | 0.0% |
| FIRST TRUST ADVISORS LP | 1,829,545 | $159.1m | 0.1% |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | $130.4m | 5.9% |
| UBS Group AG | 1,377,658 | $119.8m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,318,821 | $114.7m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,157,580 | $100.7m | 0.0% |
| MORGAN STANLEY | 1,137,559 | $98.9m | 0.0% |
| D. E. Shaw & Co., Inc. | 883,001 | $76.8m | 0.0% |
| Cerity Partners LLC | 797,119 | $69.3m | 0.1% |
| MPM BIOIMPACT LLC | 771,028 | $67.0m | 4.1% |
| NORTHERN TRUST CORP | 753,796 | $65.5m | 0.0% |
| EMERALD ADVISERS, LLC | 748,325 | $65.1m | 1.5% |
| FULLER & THALER ASSET MANAGEMENT, INC. | 710,106 | $61.7m | 0.2% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 695,532 | $60.5m | 0.2% |
| VANGUARD FIDUCIARY TRUST CO | 614,078 | $53.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 610,078 | $53.0m | 0.0% |