| FMR LLC | 32,714,937 | $122.7m | 0.0% |
| Kynam Capital Management, LP | 21,703,093 | $81.4m | 4.5% |
| BlackRock, Inc. | 17,559,822 | $65.8m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 15,082,617 | $56.6m | 0.0% |
| STATE STREET CORP | 11,747,236 | $44.1m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 10,439,185 | $39.1m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,525,457 | $32.0m | 0.0% |
| Point72 Asset Management, L.P. | 7,811,033 | $29.3m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 5,168,961 | $19.4m | 0.0% |
| Venrock Adviser, LLC | 4,982,124 | $18.7m | 0.6% |
| BAKER BROS. ADVISORS LP | 4,975,826 | $18.7m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,678,716 | $17.5m | 0.0% |
| Elmind Capital, LP | 4,550,000 | $17.1m | 4.3% |
| Nextech Invest Ltd. | 4,449,932 | $16.7m | 0.8% |
| TWO SIGMA INVESTMENTS, LP | 4,132,643 | $15.5m | 0.0% |
| Eversept Partners, LP | 3,558,497 | $13.3m | 0.7% |
| UBS Group AG | 3,468,359 | $13.0m | 0.0% |
| Siren, L.L.C. | 3,457,711 | $13.0m | 0.3% |
| ADAR1 Capital Management, LLC | 3,365,118 | $12.6m | 0.6% |
| CITADEL ADVISORS LLC | 3,110,509 | $11.7m | 0.0% |
| MARSHALL WACE, LLP | 3,024,351 | $11.3m | 0.0% |
| Woodline Partners LP | 2,040,210 | $7.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,003,652 | $7.5m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,860,290 | $7.0m | 0.0% |
| Qube Research & Technologies Ltd | 1,824,564 | $6.8m | 0.0% |