| Nantahala Capital Management, LLC | 11,204,042 | $77.8m | 1.3% |
| BlackRock, Inc. | 4,840,828 | $33.6m | 0.0% |
| BRAIDWELL LP | 3,155,209 | $21.9m | 0.8% |
| Frazier Life Sciences Management, L.P. | 2,630,665 | $18.3m | 0.4% |
| PERCEPTIVE ADVISORS LLC | 2,459,285 | $17.1m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,362,893 | $16.4m | 0.0% |
| Assenagon Asset Management S.A. | 1,816,360 | $12.6m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,787,929 | $12.4m | 0.0% |
| STATE STREET CORP | 1,697,294 | $11.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,608,394 | $11.2m | 0.0% |
| Stonepine Capital Management, LLC | 1,590,162 | $11.0m | 2.8% |
| Point72 Asset Management, L.P. | 1,508,518 | $10.5m | 0.0% |
| PINNACLE ASSOCIATES LTD | 1,487,264 | $10.3m | 0.1% |
| ARMISTICE CAPITAL, LLC | 1,436,000 | $10.0m | 0.1% |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,289,888 | $9.0m | 0.4% |
| AWH Capital, L.P. | 1,250,000 | $8.7m | 3.0% |
| GOLDMAN SACHS GROUP INC | 1,219,419 | $8.5m | 0.0% |
| Soleus Capital Management, L.P. | 822,428 | $5.7m | 0.2% |
| Soviero Asset Management, LP | 770,000 | $5.3m | 2.2% |
| UBS Group AG | 752,679 | $5.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 545,702 | $3.8m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 530,843 | $3.7m | 0.0% |
| CITADEL ADVISORS LLC | 506,354 | $3.5m | 0.0% |
| NORTHERN TRUST CORP | 497,018 | $3.4m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 456,183 | $3.2m | 0.0% |