| Frazier Life Sciences Management, L.P. | 24,975,188 | $457.5m | 10.0% |
| T. Rowe Price Investment Management, Inc. | 21,185,839 | $388.1m | 0.3% |
| BlackRock, Inc. | 21,154,146 | $387.5m | 0.0% |
| RTW INVESTMENTS, LP | 17,946,754 | $328.8m | 2.8% |
| Venrock Adviser, LLC | 17,891,812 | $327.8m | 9.9% |
| STATE STREET CORP | 12,184,555 | $223.2m | 0.0% |
| Logos Global Management LP | 12,150,000 | $222.6m | 9.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 11,402,199 | $208.9m | 0.0% |
| Siren, L.L.C. | 11,397,781 | $208.8m | 4.2% |
| Paradigm Biocapital Advisors LP | 9,550,000 | $175.0m | 3.3% |
| ARCH Venture Management, LLC | 7,091,557 | $129.9m | 11.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 6,501,426 | $119.1m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,272,508 | $114.9m | 0.0% |
| Cormorant Asset Management, LP | 6,000,000 | $109.9m | 5.6% |
| Affinity Asset Advisors, LLC | 5,250,000 | $96.2m | 4.3% |
| Vivo Capital, LLC | 4,127,412 | $75.6m | 6.9% |
| GOLDMAN SACHS GROUP INC | 3,822,113 | $70.0m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 4,118,614 | $66.6m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 3,048,737 | $55.9m | 0.0% |
| FMR LLC | 2,883,417 | $52.8m | 0.0% |
| a16z Capital Management, L.L.C. | 2,862,500 | $52.4m | 0.4% |
| Woodline Partners LP | 2,831,867 | $51.9m | 0.2% |
| JENNISON ASSOCIATES LLC | 2,788,412 | $51.1m | 0.0% |
| Soleus Capital Management, L.P. | 2,700,000 | $49.5m | 1.7% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,389,864 | $43.8m | 0.0% |