| Jupiter Topco LLC | 5,746,289 | $76.5m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 5,049,779 | $67.2m | 0.6% |
| BlackRock, Inc. | 4,546,059 | $60.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 4,258,668 | $56.6m | 0.0% |
| NOVO HOLDINGS A/S | 3,249,178 | $43.2m | 2.5% |
| STATE STREET CORP | 2,911,109 | $38.7m | 0.0% |
| BVF INC/IL | 2,879,289 | $38.3m | 1.0% |
| T. Rowe Price Investment Management, Inc. | 2,511,887 | $33.4m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,249,203 | $29.9m | 0.0% |
| Trails Edge Capital Partners, LP | 2,227,917 | $29.6m | 4.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,099,055 | $27.9m | 0.0% |
| ARMISTICE CAPITAL, LLC | 2,000,000 | $26.6m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,128,466 | $15.0m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,120,674 | $14.9m | 0.0% |
| Evergreen Quality Fund GP, Ltd. | 951,474 | $12.7m | 0.2% |
| Parkman Healthcare Partners LLC | 948,184 | $12.6m | 1.3% |
| DIMENSIONAL FUND ADVISORS LP | 730,857 | $9.7m | 0.0% |
| DEUTSCHE BANK AG\ | 710,942 | $9.5m | 0.0% |
| CITADEL ADVISORS LLC | 687,597 | $9.1m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 614,573 | $8.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 579,903 | $7.7m | 0.0% |
| DIADEMA PARTNERS LP | 571,107 | $7.6m | 0.9% |
| NORTHERN TRUST CORP | 562,929 | $7.5m | 0.0% |
| ACUTA CAPITAL PARTNERS, LLC | 507,801 | $6.8m | 4.7% |
| Nuveen, LLC | 503,071 | $6.7m | 0.0% |