| Soleus Capital Management, L.P. | 7,309,254 | $37.9m | 1.3% |
| MORGAN STANLEY | 3,336,872 | $17.3m | 0.0% |
| Rock Springs Capital Management LP | 1,386,000 | $7.2m | 0.4% |
| FLAX POND CAPITAL, LLC | 1,525,676 | $6.8m | 2.5% |
| Bruce & Co., Inc. | 438,652 | $2.3m | 0.6% |
| Parkman Healthcare Partners LLC | 154,832 | $802,030 | 0.1% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 146,005 | $756,306 | 0.1% |
| CAHILL FINANCIAL ADVISORS INC | 134,960 | $699,093 | 0.1% |
| US BANCORP \DE\ | 122,500 | $634,550 | 0.0% |
| UBS Group AG | 118,395 | $613,286 | 0.0% |
| Sage Mountain Advisors LLC | 100,000 | $518,000 | 0.0% |
| Leonteq Securities AG | 94,990 | $492,048 | 0.0% |
| Summit Trail Advisors, LLC | 82,339 | $426,516 | 0.0% |
| Cetera Investment Advisers | 74,012 | $383,382 | 0.0% |
| COMMONWEALTH EQUITY SERVICES, LLC | 69,160 | $358,250 | 0.0% |
| CITADEL ADVISORS LLC | 66,183 | $342,828 | 0.0% |
| Legato Capital Management LLC | 48,269 | $250,033 | 0.0% |
| OSAIC HOLDINGS, INC. | 42,700 | $221,186 | 0.0% |
| Schonfeld Strategic Advisors LLC | 41,730 | $216,161 | 0.0% |
| Manatuck Hill Partners, LLC | 27,597 | $142,952 | 0.0% |
| INTREPID FAMILY OFFICE LLC | 25,000 | $129,500 | 0.1% |
| SmartHarvest Portfolios, LLC | 23,933 | $123,973 | 0.0% |
| SEI INVESTMENTS CO | 23,485 | $121,652 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 22,764 | $117,917 | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,194 | $114,965 | 0.0% |