| Nantahala Capital Management, LLC | 10,950,080 | $40.1m | 0.7% |
| BlackRock, Inc. | 8,824,259 | $32.3m | 0.0% |
| EcoR1 Capital, LLC | 6,549,866 | $24.0m | 1.2% |
| TANG CAPITAL MANAGEMENT LLC | 6,521,412 | $23.9m | 1.1% |
| MONTANOVA CAPITAL, LLC | 3,680,921 | $13.5m | 0.2% |
| D. E. Shaw & Co., Inc. | 3,044,385 | $11.1m | 0.0% |
| CITADEL ADVISORS LLC | 2,704,505 | $9.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,697,216 | $9.9m | 0.0% |
| JANE STREET GROUP, LLC | 2,217,498 | $8.1m | 0.0% |
| STATE STREET CORP | 2,037,025 | $7.5m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | $7.3m | 0.0% |
| GSK plc | 1,785,714 | $6.5m | 1.1% |
| Qube Research & Technologies Ltd | 1,748,467 | $6.4m | 0.0% |
| Assenagon Asset Management S.A. | 1,670,408 | $6.1m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,647,800 | $6.0m | 0.0% |
| ADAR1 Capital Management, LLC | 1,565,029 | $5.7m | 0.3% |
| MILLENNIUM MANAGEMENT LLC | 1,485,803 | $5.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,432,133 | $5.2m | 0.0% |
| MARSHALL WACE, LLP | 1,358,423 | $5.0m | 0.0% |
| UBS Group AG | 1,253,909 | $4.6m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,180,946 | $4.3m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,103,261 | $4.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,094,425 | $4.0m | 0.0% |
| Ikarian Capital, LLC | 1,049,161 | $3.8m | 0.4% |
| BANK OF AMERICA CORP /DE/ | 1,043,029 | $3.8m | 0.0% |