| PRICE T ROWE ASSOCIATES INC /MD/ | 8,861,171 | $214.4m | 0.0% |
| NEA Management Company, LLC | 7,692,298 | $186.2m | 11.7% |
| BlackRock, Inc. | 6,843,087 | $165.6m | 0.0% |
| TCG Crossover Management, LLC | 4,622,151 | $111.9m | 2.7% |
| Vestal Point Capital, LP | 4,600,000 | $111.3m | 2.6% |
| BVF INC/IL | 4,460,886 | $108.0m | 2.8% |
| BAKER BROS. ADVISORS LP | 4,345,736 | $105.2m | 0.5% |
| STATE STREET CORP | 3,731,416 | $90.3m | 0.0% |
| MONTANOVA CAPITAL, LLC | 3,549,539 | $85.9m | 1.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,412,927 | $82.6m | 0.0% |
| Versant Venture Management, LLC | 3,180,780 | $77.0m | 47.3% |
| BRAIDWELL LP | 2,451,562 | $59.3m | 2.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,864,113 | $45.1m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 1,622,846 | $39.3m | 0.0% |
| MARSHALL WACE, LLP | 1,593,600 | $38.6m | 0.0% |
| Aisling Capital Management LP | 1,555,664 | $37.6m | 8.0% |
| Nantahala Capital Management, LLC | 1,303,986 | $31.6m | 0.5% |
| Bellevue Group AG | 1,190,000 | $28.8m | 0.6% |
| DIMENSIONAL FUND ADVISORS LP | 1,177,488 | $28.5m | 0.0% |
| MPM BIOIMPACT LLC | 1,161,081 | $28.1m | 1.7% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,108,295 | $26.8m | 2.8% |
| Jupiter Topco LLC | 1,072,494 | $26.0m | 0.0% |
| Frazier Life Sciences Management, L.P. | 1,000,000 | $24.2m | 0.5% |
| GOLDMAN SACHS GROUP INC | 998,253 | $24.2m | 0.0% |
| Woodline Partners LP | 962,884 | $23.3m | 0.1% |