| T. Rowe Price Investment Management, Inc. | 19,676,883 | $417.0m | 0.3% |
| FMR LLC | 16,987,553 | $360.0m | 0.0% |
| BlackRock, Inc. | 8,805,492 | $186.6m | 0.0% |
| STATE STREET CORP | 5,494,625 | $116.4m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 5,210,216 | $110.4m | 0.0% |
| Redmile Group, LLC | 4,911,590 | $104.1m | 7.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 4,581,431 | $97.1m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,551,289 | $96.4m | 0.0% |
| Driehaus Capital Management LLC | 4,346,139 | $92.1m | 0.5% |
| ENAVATE SCIENCES GP, LLC | 3,613,799 | $76.6m | 22.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,754,889 | $58.4m | 0.0% |
| MORGAN STANLEY | 2,407,942 | $51.0m | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,017,009 | $42.7m | 4.4% |
| JPMORGAN CHASE & CO | 1,848,548 | $39.0m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,773,229 | $37.6m | 0.0% |
| Sofinnova Investments, Inc. | 1,720,316 | $36.5m | 1.9% |
| READYSTATE ASSET MANAGEMENT LP | 1,605,820 | $34.0m | 1.2% |
| GOLDMAN SACHS GROUP INC | 1,512,489 | $32.0m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,348,979 | $28.6m | 0.0% |
| PRINCIPAL FINANCIAL GROUP INC | 1,347,358 | $28.6m | 0.0% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,250,275 | $26.5m | 0.0% |
| Woodline Partners LP | 1,000,398 | $21.2m | 0.1% |
| NORTHERN TRUST CORP | 968,346 | $20.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 886,193 | $18.8m | 0.0% |
| MetLife Investment Management, LLC | 859,076 | $18.2m | 0.1% |