| FMR LLC | 9,704,610 | $48.4m | 0.0% |
| BlackRock, Inc. | 4,374,020 | $21.8m | 0.0% |
| Sanofi | 2,708,559 | $13.5m | 2.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,286,434 | $11.4m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,936,076 | $9.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,370,750 | $6.8m | 0.0% |
| STATE STREET CORP | 1,001,995 | $5.0m | 0.0% |
| DCF Advisers, LLC | 790,000 | $3.9m | 0.7% |
| MARSHALL WACE, LLP | 731,897 | $3.7m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 601,255 | $3.0m | 0.0% |
| ALETHEA CAPITAL MANAGEMENT, LLC | 472,935 | $2.4m | 1.0% |
| Summit Financial, LLC | 452,264 | $2.3m | 0.0% |
| UBS Group AG | 448,857 | $2.2m | 0.0% |
| Nuveen, LLC | 438,362 | $2.2m | 0.0% |
| NORTHERN TRUST CORP | 436,992 | $2.2m | 0.0% |
| LEVIN CAPITAL STRATEGIES, L.P. | 414,000 | $2.1m | 0.1% |
| CITADEL ADVISORS LLC | 386,411 | $1.9m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 360,764 | $1.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 359,085 | $1.8m | 0.0% |
| GSA CAPITAL PARTNERS LLP | 343,303 | $1.7m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 330,402 | $1.6m | 0.0% |
| Burkehill Global Management, LP | 300,000 | $1.5m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 288,420 | $1.4m | 0.0% |
| MORGAN STANLEY | 226,491 | $1.1m | 0.0% |
| Occam Crest Management LP | 278,498 | $1.1m | 0.6% |