| MORGAN STANLEY | 1,308,051 | $123.9m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 1,297,763 | $123.0m | 1.8% |
| Sanofi | 1,157,926 | $109.7m | 20.5% |
| VIKING GLOBAL INVESTORS LP | 1,123,929 | $106.5m | 0.3% |
| HighTower Advisors, LLC | 870,551 | $82.5m | 0.1% |
| BANK OF AMERICA CORP /DE/ | 841,141 | $79.7m | 0.0% |
| BlackRock, Inc. | 825,972 | $78.3m | 0.0% |
| Schonfeld Strategic Advisors LLC | 697,586 | $66.1m | 0.2% |
| STATE STREET CORP | 640,458 | $60.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 492,477 | $46.7m | 0.0% |
| Woodline Partners LP | 400,892 | $38.0m | 0.1% |
| Capital Research Global Investors | 363,050 | $34.4m | 0.0% |
| GOLDMAN SACHS GROUP INC | 338,176 | $32.0m | 0.0% |
| PFM Health Sciences, LP | 308,385 | $29.2m | 2.5% |
| Sofinnova Investments, Inc. | 303,103 | $28.7m | 1.5% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 271,700 | $25.7m | 0.0% |
| Parkman Healthcare Partners LLC | 256,950 | $24.3m | 2.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 256,175 | $24.3m | 0.0% |
| First Turn Management, LLC | 164,783 | $15.6m | 1.7% |
| MILLENNIUM MANAGEMENT LLC | 147,200 | $13.9m | 0.0% |
| CDC Financial, Inc. | 140,130 | $13.3m | 5.6% |
| FIRST TRUST ADVISORS LP | 128,424 | $12.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 122,557 | $11.6m | 0.0% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | 119,200 | $11.3m | 0.0% |
| NORTHERN TRUST CORP | 100,957 | $9.6m | 0.0% |