| RA CAPITAL MANAGEMENT, L.P. | 17,754,430 | $43.5m | 0.4% |
| TCG Crossover Management, LLC | 17,754,430 | $43.4m | 1.0% |
| Versant Venture Management, LLC | 12,166,109 | $29.8m | 18.3% |
| Deep Track Capital, LP | 9,462,645 | $23.2m | 0.3% |
| RTW INVESTMENTS, LP | 8,695,652 | $21.3m | 0.2% |
| Venrock Adviser, LLC | 8,695,652 | $21.3m | 0.6% |
| Commodore Capital LP | 8,695,652 | $21.3m | 1.3% |
| BlackRock, Inc. | 8,091,768 | $19.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,703,680 | $14.0m | 0.0% |
| Balyasny Asset Management L.P. | 5,522,944 | $13.5m | 0.0% |
| Point72 Asset Management, L.P. | 4,980,526 | $12.2m | 0.0% |
| Seven Fleet Capital Management LP | 4,347,826 | $10.7m | 1.8% |
| Woodline Partners LP | 4,257,530 | $10.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 4,194,981 | $10.3m | 0.0% |
| Trails Edge Capital Partners, LP | 4,134,969 | $10.1m | 1.6% |
| Spruce Street Capital LP | 4,059,054 | $9.9m | 2.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,789,538 | $9.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,979,529 | $7.3m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,699,013 | $6.6m | 0.0% |
| DAFNA Capital Management LLC | 2,400,458 | $5.9m | 1.1% |
| STEMPOINT CAPITAL LP | 2,146,182 | $5.3m | 0.9% |
| STATE STREET CORP | 1,843,154 | $4.5m | 0.0% |
| NORTHERN TRUST CORP | 1,593,944 | $3.9m | 0.0% |
| DV Trading LLC | 1,400,000 | $3.4m | 0.1% |
| Rock Springs Capital Management LP | 1,304,347 | $3.2m | 0.2% |