| FMR LLC | 9,126,877 | $202.8m | 0.0% |
| Jupiter Topco LLC | 6,273,262 | $139.4m | 0.1% |
| Fairmount Funds Management LLC | 4,553,494 | $101.2m | 6.7% |
| RA CAPITAL MANAGEMENT, L.P. | 3,671,083 | $81.6m | 0.7% |
| Venrock Adviser, LLC | 3,220,364 | $71.6m | 2.2% |
| Bellevue Group AG | 3,057,996 | $67.9m | 1.4% |
| Paradigm Biocapital Advisors LP | 2,857,405 | $63.5m | 1.2% |
| BlackRock, Inc. | 2,801,451 | $62.2m | 0.0% |
| FRANKLIN RESOURCES INC | 2,792,080 | $62.0m | 0.0% |
| STATE STREET CORP | 2,335,285 | $51.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,244,773 | $49.9m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,910,812 | $42.5m | 0.1% |
| Polar Capital Holdings Plc | 1,846,982 | $41.0m | 0.1% |
| Avidity Partners Management LP | 1,700,708 | $37.8m | 6.1% |
| Remedium Capital Partners, LLC | 1,577,750 | $35.1m | 7.8% |
| Soleus Capital Management, L.P. | 1,550,690 | $34.5m | 1.2% |
| JPMORGAN CHASE & CO | 1,475,079 | $32.6m | 0.0% |
| BAKER BROS. ADVISORS LP | 1,230,426 | $27.3m | 0.1% |
| Logos Global Management LP | 1,125,000 | $25.0m | 1.1% |
| Versant Venture Management, LLC | 991,783 | $22.0m | 13.6% |
| ACORN CAPITAL ADVISORS, LLC | 986,760 | $21.9m | 6.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 985,178 | $21.9m | 0.0% |
| CITADEL ADVISORS LLC | 929,407 | $20.7m | 0.0% |
| Foresite Capital Management VI LLC | 886,667 | $19.7m | 3.1% |
| Balyasny Asset Management L.P. | 878,726 | $19.5m | 0.0% |