| Lynx1 Capital Management LP | 1,538,296 | $20.3m | 2.3% |
| Nantahala Capital Management, LLC | 1,320,072 | $17.4m | 0.3% |
| NEA Management Company, LLC | 1,297,893 | $17.1m | 1.1% |
| Venrock Adviser, LLC | 1,009,500 | $13.3m | 0.4% |
| Atlas Venture Life Science Advisors, LLC | 962,884 | $12.7m | 1.4% |
| Balyasny Asset Management L.P. | 951,783 | $12.5m | 0.0% |
| BlackRock, Inc. | 817,621 | $10.8m | 0.0% |
| Affinity Asset Advisors, LLC | 706,904 | $9.3m | 0.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 540,968 | $7.1m | 0.0% |
| ADAR1 Capital Management, LLC | 540,054 | $7.1m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 454,778 | $6.0m | 0.0% |
| Driehaus Capital Management LLC | 450,045 | $5.9m | 0.0% |
| TCG Crossover Management, LLC | 416,301 | $5.5m | 0.1% |
| Kalehua Capital Management LLC | 405,040 | $5.3m | 1.7% |
| Siren, L.L.C. | 347,718 | $4.6m | 0.1% |
| AQR CAPITAL MANAGEMENT LLC | 298,974 | $3.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 296,870 | $3.9m | 0.0% |
| 72 Investment Holdings, LLC | 276,831 | $3.6m | 7.3% |
| STATE STREET CORP | 232,587 | $3.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 223,551 | $2.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 178,071 | $2.3m | 0.0% |
| JPMORGAN CHASE & CO | 124,726 | $1.6m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 118,434 | $1.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 116,983 | $1.5m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 110,524 | $1.5m | 0.0% |