| Deep Track Capital, LP | 3,352,804 | $108.8m | 1.6% |
| BlackRock, Inc. | 2,734,305 | $88.7m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 2,208,604 | $71.7m | 0.6% |
| Nantahala Capital Management, LLC | 2,105,788 | $68.3m | 1.1% |
| Trails Edge Capital Partners, LP | 1,523,022 | $49.4m | 7.8% |
| JPMORGAN CHASE & CO | 1,497,293 | $48.9m | 0.0% |
| Commodore Capital LP | 1,500,000 | $48.7m | 2.9% |
| TCG Crossover Management, LLC | 1,447,310 | $47.0m | 1.1% |
| Caligan Partners LP | 1,438,070 | $46.7m | 2.2% |
| Spruce Street Capital LP | 1,376,159 | $44.7m | 8.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 971,165 | $31.5m | 0.0% |
| Balyasny Asset Management L.P. | 921,471 | $29.9m | 0.0% |
| Alyeska Investment Group, L.P. | 863,947 | $28.0m | 0.1% |
| Vivo Capital, LLC | 800,000 | $26.0m | 2.4% |
| Nan Fung Group Holdings Ltd | 630,657 | $20.5m | 15.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 612,793 | $19.9m | 0.0% |
| STATE STREET CORP | 602,028 | $19.5m | 0.0% |
| Logos Global Management LP | 585,000 | $19.0m | 0.8% |
| GOLDMAN SACHS GROUP INC | 576,456 | $18.7m | 0.0% |
| JENNISON ASSOCIATES LLC | 540,902 | $17.6m | 0.0% |
| GREAT POINT PARTNERS LLC | 317,221 | $10.3m | 1.9% |
| BOOTHBAY FUND MANAGEMENT, LLC | 275,675 | $8.9m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 259,219 | $8.4m | 0.0% |
| AMERIPRISE FINANCIAL INC | 227,485 | $7.4m | 0.0% |
| CITADEL ADVISORS LLC | 215,969 | $7.0m | 0.0% |