| MONTANOVA CAPITAL, LLC | 6,384,200 | $29.7m | 0.5% |
| Affinity Asset Advisors, LLC | 5,807,611 | $27.0m | 1.2% |
| BlackRock, Inc. | 5,739,455 | $26.7m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 5,000,000 | $23.3m | 0.2% |
| Frazier Life Sciences Management, L.P. | 4,824,725 | $22.5m | 0.5% |
| STATE STREET CORP | 4,354,757 | $20.3m | 0.0% |
| Vestal Point Capital, LP | 4,320,000 | $20.1m | 0.5% |
| Paradigm Biocapital Advisors LP | 4,175,382 | $19.4m | 0.4% |
| Jupiter Topco LLC | 3,954,691 | $18.4m | 0.0% |
| ORBIMED ADVISORS LLC | 3,947,850 | $18.4m | 0.3% |
| CITADEL ADVISORS LLC | 3,898,570 | $18.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,125,893 | $14.6m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,833,622 | $13.2m | 0.0% |
| Nantahala Capital Management, LLC | 2,600,000 | $12.1m | 0.2% |
| Woodline Partners LP | 2,500,532 | $11.6m | 0.0% |
| Balyasny Asset Management L.P. | 2,412,742 | $11.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,149,612 | $10.0m | 0.0% |
| 683 Capital Management, LLC | 1,875,000 | $8.7m | 0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,747,959 | $8.1m | 0.0% |
| ADAR1 Capital Management, LLC | 1,565,950 | $7.3m | 0.3% |
| Avoro Capital Advisors LLC | 1,489,189 | $6.9m | 0.1% |
| Qube Research & Technologies Ltd | 1,376,222 | $6.4m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,287,185 | $6.0m | 0.0% |
| Spruce Street Capital LP | 928,593 | $4.3m | 0.8% |
| Blackstone Inc. | 904,959 | $4.2m | 0.0% |