| Frazier Life Sciences Management, L.P. | 5,032,915 | $150.2m | 3.3% |
| TRV GP IV, LLC | 4,473,958 | $133.5m | 52.6% |
| ARCH Venture Management, LLC | 4,120,053 | $123.0m | 11.2% |
| Deep Track Capital, LP | 3,732,569 | $111.4m | 1.6% |
| BlackRock, Inc. | 3,502,841 | $104.5m | 0.0% |
| Jupiter Topco LLC | 3,408,045 | $101.8m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 2,603,682 | $77.7m | 0.1% |
| Logos Global Management LP | 1,935,000 | $57.7m | 2.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,778,222 | $53.1m | 0.0% |
| a16z Capital Management, L.L.C. | 1,702,225 | $50.8m | 0.4% |
| Venrock Adviser, LLC | 1,602,034 | $47.8m | 1.4% |
| Alphabet Inc. | 1,388,583 | $41.4m | 0.0% |
| BRAIDWELL LP | 1,140,040 | $34.0m | 1.3% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 1,107,814 | $33.1m | 0.2% |
| FMR LLC | 1,056,959 | $31.5m | 0.0% |
| General Catalyst Group Management, LLC | 1,035,910 | $30.9m | 16.4% |
| STATE STREET CORP | 997,533 | $29.8m | 0.0% |
| Driehaus Capital Management LLC | 954,886 | $28.5m | 0.2% |
| TRV GP V, LLC | 950,800 | $28.4m | 5.7% |
| JPMORGAN CHASE & CO | 964,011 | $28.0m | 0.0% |
| MARSHALL WACE, LLP | 914,572 | $27.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 858,054 | $25.6m | 0.0% |
| CITADEL ADVISORS LLC | 852,676 | $25.4m | 0.0% |
| Casdin Capital, LLC | 843,857 | $25.2m | 1.3% |
| ArrowMark Colorado Holdings LLC | 767,383 | $22.9m | 1.0% |