| Frazier Life Sciences Management, L.P. | 6,652,013 | $367.2m | 8.0% |
| FMR LLC | 5,322,885 | $293.8m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 4,977,523 | $274.8m | 0.0% |
| NEA Management Company, LLC | 3,614,486 | $199.5m | 12.6% |
| ORBIMED ADVISORS LLC | 3,428,736 | $189.3m | 3.5% |
| BlackRock, Inc. | 3,323,672 | $183.5m | 0.0% |
| Paradigm Biocapital Advisors LP | 2,508,015 | $138.4m | 2.6% |
| NVP ASSOCIATES, LLC | 2,136,335 | $117.9m | 35.9% |
| Deep Track Capital, LP | 1,732,569 | $95.6m | 1.4% |
| Polar Capital Holdings Plc | 1,608,514 | $88.8m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,477,388 | $81.6m | 0.0% |
| Aaron Wealth Advisors LLC | 1,167,799 | $64.5m | 3.3% |
| Driehaus Capital Management LLC | 1,056,579 | $58.3m | 0.3% |
| Kynam Capital Management, LP | 934,799 | $51.6m | 2.9% |
| Woodline Partners LP | 900,092 | $49.7m | 0.2% |
| EVENTIDE ASSET MANAGEMENT, LLC | 873,492 | $48.2m | 0.6% |
| STATE STREET CORP | 864,466 | $47.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 814,807 | $45.0m | 0.0% |
| Parkman Healthcare Partners LLC | 800,173 | $44.2m | 4.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 773,072 | $42.7m | 0.0% |
| BRAIDWELL LP | 710,880 | $39.2m | 1.5% |
| TCG Crossover Management, LLC | 650,000 | $35.9m | 0.9% |
| Cormorant Asset Management, LP | 550,000 | $30.4m | 1.6% |
| Soleus Capital Management, L.P. | 515,279 | $28.4m | 1.0% |
| GOLDMAN SACHS GROUP INC | 459,005 | $25.3m | 0.0% |