| Frazier Life Sciences Management, L.P. | 7,679,684 | $899.1m | 19.6% |
| Jupiter Topco LLC | 5,909,184 | $691.7m | 0.3% |
| BlackRock, Inc. | 4,390,063 | $513.9m | 0.0% |
| FMR LLC | 3,670,314 | $429.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,655,607 | $310.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,377,019 | $278.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,254,109 | $263.9m | 0.0% |
| STATE STREET CORP | 2,170,689 | $254.1m | 0.0% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,404,741 | $164.5m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,393,908 | $163.2m | 0.0% |
| Invesco Ltd. | 1,364,084 | $159.7m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,309,987 | $153.4m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,248,389 | $146.2m | 2.0% |
| TANG CAPITAL MANAGEMENT LLC | 1,236,027 | $144.7m | 6.6% |
| Capital World Investors | 1,153,480 | $135.0m | 0.0% |
| FRANKLIN RESOURCES INC | 1,152,770 | $135.0m | 0.0% |
| NOVO HOLDINGS A/S | 1,125,000 | $131.7m | 7.6% |
| TCG Crossover Management, LLC | 1,062,049 | $124.3m | 3.0% |
| BVF INC/IL | 1,056,027 | $123.6m | 3.2% |
| Polar Capital Holdings Plc | 845,524 | $99.0m | 0.2% |
| Rock Springs Capital Management LP | 798,145 | $93.4m | 4.6% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 752,044 | $88.0m | 0.1% |
| AMERIPRISE FINANCIAL INC | 726,694 | $85.1m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 690,318 | $80.8m | 0.1% |
| Bank of New York Mellon Corp | 669,974 | $78.4m | 0.0% |