| BVF INC/IL | 16,001,284 | $311.5m | 8.0% |
| Deep Track Capital, LP | 6,999,025 | $136.3m | 2.0% |
| T. Rowe Price Investment Management, Inc. | 4,280,624 | $83.3m | 0.1% |
| D. E. Shaw & Co., Inc. | 3,365,507 | $65.5m | 0.0% |
| Cormorant Asset Management, LP | 3,205,433 | $62.4m | 3.2% |
| Jupiter Topco LLC | 3,085,906 | $60.1m | 0.0% |
| Logos Global Management LP | 2,675,000 | $52.1m | 2.2% |
| Weiss Asset Management LP | 2,581,813 | $50.3m | 0.5% |
| CITADEL ADVISORS LLC | 1,972,893 | $38.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,715,349 | $33.4m | 0.0% |
| MPM BIOIMPACT LLC | 1,606,967 | $31.3m | 1.9% |
| JPMORGAN CHASE & CO | 1,386,422 | $27.6m | 0.0% |
| Vivo Capital, LLC | 1,400,000 | $27.3m | 2.5% |
| Point72 Asset Management, L.P. | 1,158,732 | $22.6m | 0.0% |
| BlackRock, Inc. | 1,094,791 | $21.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,041,527 | $20.3m | 0.0% |
| Balyasny Asset Management L.P. | 912,715 | $17.8m | 0.0% |
| GREAT POINT PARTNERS LLC | 855,813 | $16.7m | 3.1% |
| JANE STREET GROUP, LLC | 853,386 | $16.6m | 0.0% |
| Candriam S.C.A. | 769,766 | $15.0m | 0.1% |
| BANK OF AMERICA CORP /DE/ | 751,897 | $14.6m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 750,777 | $14.6m | 0.0% |
| Trails Edge Capital Partners, LP | 750,000 | $14.6m | 2.3% |
| HRT FINANCIAL LP | 679,244 | $13.2m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 643,268 | $12.5m | 0.0% |