| Catalys Pacific, LLC | 7,903,838 | $213.2m | 92.9% |
| RA CAPITAL MANAGEMENT, L.P. | 7,692,750 | $207.6m | 1.8% |
| BlackRock, Inc. | 5,887,038 | $158.8m | 0.0% |
| SAMSARA BIOCAPITAL, LLC | 5,871,018 | $158.4m | 13.0% |
| FMR LLC | 4,511,689 | $121.7m | 0.0% |
| STATE STREET CORP | 4,141,636 | $111.7m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,958,000 | $106.8m | 1.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,756,770 | $74.4m | 0.0% |
| Laurion Capital Management LP | 2,506,152 | $67.6m | 1.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,262,476 | $61.0m | 0.0% |
| ORBIMED ADVISORS LLC | 2,110,300 | $56.9m | 1.1% |
| Capital World Investors | 1,997,607 | $53.9m | 0.0% |
| ARMISTICE CAPITAL, LLC | 1,736,000 | $46.8m | 0.6% |
| Troluce Capital Advisors LLC | 1,728,753 | $46.6m | 4.8% |
| Nantahala Capital Management, LLC | 1,640,962 | $44.3m | 0.7% |
| FRANKLIN RESOURCES INC | 1,635,520 | $44.1m | 0.0% |
| ANDERA PARTNERS | 1,591,917 | $42.9m | 20.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,584,326 | $42.8m | 0.0% |
| SR One Capital Management, LP | 1,563,966 | $42.2m | 4.1% |
| BANK OF AMERICA CORP /DE/ | 1,505,547 | $40.6m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 1,469,971 | $39.7m | 5.2% |
| GOLDMAN SACHS GROUP INC | 1,458,676 | $39.4m | 0.0% |
| Pictet Asset Management Holding SA | 1,430,649 | $38.6m | 0.0% |
| Polar Capital Holdings Plc | 1,420,854 | $38.3m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 1,221,758 | $33.0m | 0.0% |