| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | $30.6m | 0.3% |
| BlackRock, Inc. | 6,300,212 | $17.8m | 0.0% |
| NEA Management Company, LLC | 3,568,781 | $10.1m | 0.6% |
| SAMSARA BIOCAPITAL, LLC | 3,507,666 | $9.9m | 0.8% |
| SR One Capital Management, LP | 3,333,333 | $9.4m | 0.9% |
| GSK plc | 3,150,732 | $8.9m | 1.5% |
| Monaco Asset Management SAM | 2,373,400 | $6.7m | 0.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,226,415 | $6.3m | 0.0% |
| CITADEL ADVISORS LLC | 2,174,745 | $6.2m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,873,293 | $5.3m | 0.0% |
| WASATCH ADVISORS LP | 1,577,847 | $4.5m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,360,548 | $3.8m | 0.0% |
| STATE STREET CORP | 1,286,109 | $3.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,285,507 | $3.6m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,177,652 | $3.3m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,054,251 | $3.0m | 0.0% |
| AWM Investment Company, Inc. | 906,000 | $2.6m | 0.2% |
| Blackstone Inc. | 747,044 | $2.1m | 0.0% |
| MARSHALL WACE, LLP | 673,010 | $1.9m | 0.0% |
| PANAGORA ASSET MANAGEMENT INC | 583,249 | $1.7m | 0.0% |
| JPMORGAN CHASE & CO | 562,980 | $1.6m | 0.0% |
| Peapod Lane Capital LLC | 549,923 | $1.6m | 1.1% |
| Alyeska Investment Group, L.P. | 484,840 | $1.4m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 483,211 | $1.4m | 0.0% |
| Nuveen, LLC | 469,555 | $1.3m | 0.0% |