| Siren, L.L.C. | 8,497,822 | $14.4m | 0.3% |
| BlackRock, Inc. | 7,791,869 | $13.2m | 0.0% |
| SOFTBANK GROUP CORP. | 6,090,301 | $10.4m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,669,585 | $7.9m | 0.0% |
| MIC Capital Management UK LLP | 4,460,700 | $7.6m | 1.9% |
| FMR LLC | 3,498,869 | $5.9m | 0.0% |
| WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 3,309,123 | $5.6m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,607,289 | $4.4m | 0.0% |
| ICONIQ Capital, LLC | 2,559,090 | $4.4m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 2,244,829 | $3.8m | 0.0% |
| ORBIMED ADVISORS LLC | 2,139,882 | $3.6m | 0.1% |
| Lunate Capital Ltd | 2,124,143 | $3.6m | 1.8% |
| Boxer Capital Management, LLC | 2,000,000 | $3.4m | 0.3% |
| JOHNSON & JOHNSON | 1,849,445 | $3.1m | 0.4% |
| STATE STREET CORP | 1,582,119 | $2.7m | 0.0% |
| TUDOR INVESTMENT CORP ET AL | 1,356,147 | $2.3m | 0.0% |
| Ikarian Capital, LLC | 1,278,408 | $2.2m | 0.2% |
| RENAISSANCE TECHNOLOGIES LLC | 1,262,304 | $2.1m | 0.0% |
| Affinity Asset Advisors, LLC | 1,070,651 | $1.8m | 0.1% |
| MARSHALL WACE, LLP | 904,458 | $1.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 894,791 | $1.5m | 0.0% |
| CITADEL ADVISORS LLC | 828,933 | $1.4m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 823,583 | $1.4m | 0.0% |
| NORTHERN TRUST CORP | 800,571 | $1.4m | 0.0% |
| Ensign Peak Advisors, Inc | 784,679 | $1.3m | 0.0% |