| Polar Capital Holdings Plc | 3,298,104 | $52.4m | 0.1% |
| Soleus Capital Management, L.P. | 2,911,122 | $46.3m | 1.6% |
| First Light Asset Management, LLC | 2,861,167 | $45.5m | 2.8% |
| MORGAN STANLEY | 2,654,391 | $42.2m | 0.0% |
| BlackRock, Inc. | 2,477,603 | $39.4m | 0.0% |
| ORBIMED ADVISORS LLC | 1,505,125 | $23.9m | 0.4% |
| Driehaus Capital Management LLC | 1,447,391 | $23.0m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,227,072 | $19.5m | 0.0% |
| DEUTSCHE BANK AG\ | 938,919 | $14.9m | 0.0% |
| ARMISTICE CAPITAL, LLC | 692,000 | $11.0m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 666,300 | $10.6m | 0.0% |
| FMR LLC | 554,771 | $8.8m | 0.0% |
| STATE STREET CORP | 550,132 | $8.7m | 0.0% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 344,124 | $5.5m | 0.0% |
| NORTHERN TRUST CORP | 260,025 | $4.1m | 0.0% |
| Qube Research & Technologies Ltd | 221,237 | $3.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 220,371 | $3.5m | 0.0% |
| Palumbo Wealth Management LLC | 209,199 | $3.3m | 0.7% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 208,703 | $3.3m | 0.4% |
| ALGERT GLOBAL LLC | 184,774 | $2.9m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 182,534 | $2.9m | 0.0% |
| JPMORGAN CHASE & CO | 173,311 | $2.9m | 0.0% |
| HighMark Wealth Management LLC | 163,000 | $2.6m | 0.9% |
| Russell Investments Group, Ltd. | 162,164 | $2.6m | 0.0% |
| D. E. Shaw & Co., Inc. | 161,081 | $2.6m | 0.0% |