| BlackRock, Inc. | 8,770,349 | $212.8m | 0.0% |
| Vestal Point Capital, LP | 8,050,000 | $195.3m | 4.6% |
| Deep Track Capital, LP | 7,736,455 | $187.7m | 2.7% |
| Rubric Capital Management LP | 7,227,778 | $175.3m | 1.6% |
| FMR LLC | 5,485,215 | $133.1m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,436,587 | $131.9m | 0.0% |
| MORGAN STANLEY | 4,762,484 | $115.5m | 0.0% |
| STATE STREET CORP | 4,677,244 | $113.5m | 0.0% |
| BAKER BROS. ADVISORS LP | 4,658,556 | $113.0m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,495,529 | $109.1m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 4,320,422 | $104.8m | 1.6% |
| Redmile Group, LLC | 4,073,787 | $98.8m | 6.6% |
| GENERAL ATLANTIC, L.P. | 3,032,185 | $73.6m | 2.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,537,291 | $61.6m | 0.0% |
| Pictet Asset Management Holding SA | 2,351,232 | $57.0m | 0.1% |
| ARK Investment Management LLC | 1,793,196 | $43.5m | 0.3% |
| Capital World Investors | 1,787,916 | $43.4m | 0.0% |
| Trails Edge Capital Partners, LP | 1,573,220 | $38.2m | 6.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,482,861 | $36.0m | 0.0% |
| CITADEL ADVISORS LLC | 1,477,019 | $35.8m | 0.0% |
| Soleus Capital Management, L.P. | 1,465,163 | $35.5m | 1.2% |
| DIMENSIONAL FUND ADVISORS LP | 1,431,317 | $34.7m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,297,893 | $31.5m | 0.4% |
| BRAIDWELL LP | 1,286,769 | $31.2m | 1.2% |
| Kynam Capital Management, LP | 1,194,757 | $29.0m | 1.6% |