| MORGAN STANLEY | 11,721,609 | $28.5m | 0.0% |
| Soleus Capital Management, L.P. | 10,140,951 | $24.6m | 0.8% |
| BlackRock, Inc. | 7,249,528 | $17.6m | 0.0% |
| Assenagon Asset Management S.A. | 3,935,904 | $9.6m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 3,050,297 | $7.4m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 3,011,753 | $7.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,905,919 | $7.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 2,888,313 | $7.0m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,935,554 | $4.7m | 0.0% |
| DEUTSCHE BANK AG\ | 1,706,186 | $4.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,607,729 | $3.9m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,545,086 | $3.7m | 0.0% |
| STATE STREET CORP | 1,519,955 | $3.7m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,017,113 | $2.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 905,024 | $2.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 887,399 | $2.2m | 0.0% |
| CITADEL ADVISORS LLC | 867,929 | $2.1m | 0.0% |
| FLAX POND CAPITAL, LLC | 842,682 | $2.0m | 0.7% |
| SG Americas Securities, LLC | 772,737 | $1.9m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 692,197 | $1.7m | 0.0% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 628,700 | $1.5m | 0.0% |
| NORTHERN TRUST CORP | 584,577 | $1.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 563,048 | $1.4m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 550,000 | $1.3m | 0.2% |
| NORGES BANK | 530,900 | $1.3m | 0.0% |