| BlackRock, Inc. | 46,153,124 | $501.7m | 0.0% |
| Tetragon Partners GP Ltd | 30,950,000 | $336.4m | 53.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 26,320,700 | $286.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 18,710,688 | $203.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 15,034,443 | $163.4m | 0.1% |
| STATE STREET CORP | 13,832,188 | $150.4m | 0.0% |
| Senvest Management, LLC | 12,085,222 | $131.4m | 3.9% |
| BANK OF AMERICA CORP /DE/ | 11,292,532 | $122.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 8,154,846 | $88.7m | 0.0% |
| UBS Group AG | 8,132,417 | $88.4m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 7,975,364 | $86.7m | 0.0% |
| MORGAN STANLEY | 7,657,130 | $83.2m | 0.0% |
| JUPITER ASSET MANAGEMENT LTD | 7,561,364 | $82.2m | 0.4% |
| FEDERATED HERMES, INC. | 7,059,895 | $76.7m | 0.1% |
| Alphabet Inc. | 7,034,337 | $76.5m | 0.1% |
| GOLDMAN SACHS GROUP INC | 6,697,811 | $72.8m | 0.0% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,453,246 | $59.3m | 0.1% |
| NORGES BANK | 4,785,128 | $52.0m | 0.0% |
| D. E. Shaw & Co., Inc. | 4,719,704 | $51.3m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,005,775 | $43.5m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 3,553,900 | $38.6m | 0.1% |
| NEUBERGER BERMAN GROUP LLC | 3,266,116 | $35.5m | 0.0% |
| NORTHERN TRUST CORP | 3,226,181 | $35.1m | 0.0% |
| JPMORGAN CHASE & CO | 2,896,972 | $31.1m | 0.0% |
| Bank of New York Mellon Corp | 2,826,701 | $30.7m | 0.0% |