| RA CAPITAL MANAGEMENT, L.P. | 20,064,545 | $36.1m | 0.3% |
| Commodore Capital LP | 4,475,000 | $8.1m | 0.5% |
| VIKING GLOBAL INVESTORS LP | 3,482,434 | $6.3m | 0.0% |
| Laurion Capital Management LP | 2,750,855 | $5.0m | 0.1% |
| ADAR1 Capital Management, LLC | 2,591,085 | $4.7m | 0.2% |
| Vivo Capital, LLC | 2,325,000 | $4.2m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,935,920 | $3.5m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,786,765 | $3.2m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,520,246 | $2.7m | 0.0% |
| BlackRock, Inc. | 1,304,262 | $2.3m | 0.0% |
| MARSHALL WACE, LLP | 866,992 | $1.6m | 0.0% |
| GSA CAPITAL PARTNERS LLP | 852,852 | $1.5m | 0.1% |
| CITADEL ADVISORS LLC | 658,381 | $1.2m | 0.0% |
| AWM Investment Company, Inc. | 600,000 | $1.1m | 0.1% |
| MONIMUS CAPITAL MANAGEMENT, LP | 587,688 | $1.1m | 0.2% |
| Squarepoint Ops LLC | 529,083 | $952,349 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 523,473 | $942,806 | 0.0% |
| Creek Drive Management Group LLC | 450,000 | $810,000 | 0.4% |
| Ikarian Capital, LLC | 447,165 | $804,897 | 0.1% |
| DIADEMA PARTNERS LP | 373,284 | $671,911 | 0.1% |
| BOOTHBAY FUND MANAGEMENT, LLC | 366,141 | $659,054 | 0.0% |
| Rosalind Advisors, Inc. | 350,000 | $630,000 | 0.2% |
| Driehaus Capital Management LLC | 279,909 | $503,836 | 0.0% |
| Boxer Capital Management, LLC | 272,892 | $491,206 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 261,476 | $470,657 | 0.0% |