| TANG CAPITAL MANAGEMENT LLC | 6,141,261 | $7.0m | 0.3% |
| ADAR1 Capital Management, LLC | 5,509,724 | $6.3m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,440,351 | $2.8m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 2,416,508 | $2.7m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,262,832 | $2.6m | 0.0% |
| CITADEL ADVISORS LLC | 2,142,226 | $2.4m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 2,049,874 | $2.3m | 0.0% |
| Monaco Asset Management SAM | 1,938,747 | $2.2m | 0.2% |
| Lynx1 Capital Management LP | 1,798,070 | $2.0m | 0.2% |
| BML Capital Management, LLC | 1,546,137 | $1.8m | 1.0% |
| Prosight Management, LP | 1,370,233 | $1.6m | 0.3% |
| Peapod Lane Capital LLC | 1,309,013 | $1.5m | 1.0% |
| Woodline Partners LP | 1,296,534 | $1.5m | 0.0% |
| BlackRock, Inc. | 1,151,214 | $1.3m | 0.0% |
| Ikarian Capital, LLC | 1,000,000 | $1.1m | 0.1% |
| Eversept Partners, LP | 891,425 | $1.0m | 0.1% |
| MARSHALL WACE, LLP | 835,124 | $952,041 | 0.0% |
| Redmile Group, LLC | 772,126 | $880,224 | 0.1% |
| JPMORGAN CHASE & CO | 681,647 | $783,894 | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 643,120 | $733,157 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 578,577 | $659,954 | 0.0% |
| UBS Group AG | 571,760 | $651,806 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 559,447 | $637,770 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 553,630 | $631,138 | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 536,081 | $611,132 | 0.0% |