| BML Capital Management, LLC | 5,330,000 | $7.1m | 4.1% |
| TANG CAPITAL MANAGEMENT LLC | 4,245,085 | $5.7m | 0.3% |
| Sio Capital Management, LLC | 2,634,137 | $3.5m | 0.6% |
| Euclidean Capital LLC | 2,627,643 | $3.5m | 0.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,360,000 | $3.2m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 2,215,894 | $3.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,012,020 | $2.7m | 0.0% |
| ArrowMark Colorado Holdings LLC | 1,959,579 | $2.6m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 1,954,136 | $2.6m | 0.0% |
| Eversept Partners, LP | 1,890,904 | $2.5m | 0.1% |
| BlackRock, Inc. | 919,818 | $1.2m | 0.0% |
| Assenagon Asset Management S.A. | 660,006 | $884,408 | 0.0% |
| Stonepine Capital Management, LLC | 536,086 | $718,355 | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 473,158 | $634,624 | 0.0% |
| Aldebaran Capital, LLC | 467,432 | $626,359 | 0.5% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 428,853 | $574,663 | 0.0% |
| BIT Capital GmbH | 407,555 | $546,124 | 0.0% |
| Verdad Advisers, LP | 362,361 | $485,564 | 0.5% |
| Walleye Capital LLC | 335,694 | $449,830 | 0.0% |
| MARSHALL WACE, LLP | 321,610 | $430,956 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 254,775 | $341,399 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 240,110 | $321,747 | 0.0% |
| ADAR1 Capital Management, LLC | 201,008 | $269,351 | 0.0% |
| STATE STREET CORP | 183,178 | $245,459 | 0.0% |
| RBF Capital, LLC | 162,200 | $217,348 | 0.0% |