| Merck & Co., Inc. | 14,044,943 | $188.2m | 35.8% |
| ARK Investment Management LLC | 8,271,339 | $110.8m | 0.7% |
| BlackRock, Inc. | 7,082,491 | $94.9m | 0.0% |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 6,101,850 | $81.8m | 3.4% |
| AMERIPRISE FINANCIAL INC | 6,086,315 | $81.6m | 0.0% |
| Deep Track Capital, LP | 4,000,000 | $53.6m | 0.8% |
| Aberdeen Group plc | 3,747,290 | $50.2m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,010,150 | $40.3m | 0.0% |
| Casdin Capital, LLC | 2,550,000 | $34.2m | 1.7% |
| KENNEDY CAPITAL MANAGEMENT LLC | 2,364,282 | $31.7m | 0.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,822,445 | $24.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,820,541 | $24.4m | 0.0% |
| AIGH Capital Management LLC | 1,715,000 | $23.0m | 1.4% |
| Blue Water Life Science Advisors, LP | 1,676,300 | $22.5m | 14.1% |
| DIMENSIONAL FUND ADVISORS LP | 1,496,983 | $20.1m | 0.0% |
| STATE STREET CORP | 1,487,077 | $19.9m | 0.0% |
| MORGAN STANLEY | 1,270,946 | $17.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 931,031 | $12.5m | 0.0% |
| HRT FINANCIAL LP | 930,816 | $12.5m | 0.0% |
| Nuveen, LLC | 753,004 | $10.1m | 0.0% |
| JANE STREET GROUP, LLC | 738,241 | $9.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 659,834 | $8.8m | 0.0% |
| NORTHERN TRUST CORP | 632,803 | $8.5m | 0.0% |
| Trexquant Investment LP | 600,216 | $8.0m | 0.0% |
| HOWLAND CAPITAL MANAGEMENT LLC | 555,641 | $7.4m | 0.3% |