| BlackRock, Inc. | 6,397,440 | $76.6m | 0.0% |
| Redmile Group, LLC | 4,368,804 | $52.3m | 3.5% |
| STATE STREET CORP | 2,971,173 | $35.6m | 0.0% |
| JPMORGAN CHASE & CO | 2,214,169 | $26.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,107,557 | $25.2m | 0.0% |
| MORGAN STANLEY | 1,953,237 | $23.4m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,421,453 | $17.0m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,378,358 | $16.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,355,554 | $16.2m | 0.0% |
| MARSHALL WACE, LLP | 1,284,950 | $15.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,241,296 | $14.9m | 0.0% |
| Integral Health Asset Management, LLC | 800,000 | $9.6m | 0.4% |
| Nuveen, LLC | 740,026 | $8.9m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 731,586 | $8.8m | 0.0% |
| D. E. Shaw & Co., Inc. | 712,814 | $8.5m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 669,808 | $8.0m | 0.0% |
| CITADEL ADVISORS LLC | 669,023 | $8.0m | 0.0% |
| STIFEL FINANCIAL CORP | 560,727 | $6.7m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 518,545 | $6.2m | 0.0% |
| 22NW, LP | 492,759 | $5.9m | 5.6% |
| MILLENNIUM MANAGEMENT LLC | 480,762 | $5.8m | 0.0% |
| Pale Fire Capital SE | 466,209 | $5.6m | 0.4% |
| NORTHERN TRUST CORP | 421,839 | $5.1m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 396,450 | $4.7m | 0.0% |
| LAZARD ASSET MANAGEMENT LLC | 370,375 | $4.4m | 0.0% |