| FEDERATED HERMES, INC. | 12,990,659 | $67.6m | 0.1% |
| RA CAPITAL MANAGEMENT, L.P. | 9,445,039 | $49.1m | 0.4% |
| BlackRock, Inc. | 7,718,291 | $40.1m | 0.0% |
| Opaleye Management Inc. | 6,300,000 | $32.8m | 3.0% |
| Balyasny Asset Management L.P. | 4,662,039 | $24.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,835,827 | $19.9m | 0.0% |
| Siren, L.L.C. | 3,328,287 | $17.3m | 0.4% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,561,654 | $13.3m | 0.0% |
| JENNISON ASSOCIATES LLC | 2,459,308 | $12.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,170,154 | $11.3m | 0.0% |
| STATE STREET CORP | 1,850,128 | $9.6m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,839,357 | $9.6m | 0.0% |
| MORGAN STANLEY | 1,618,783 | $8.4m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,380,746 | $7.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,316,782 | $6.8m | 0.0% |
| Nuveen, LLC | 1,295,209 | $6.7m | 0.0% |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,221,678 | $6.4m | 0.1% |
| Blackstone Inc. | 1,082,927 | $5.6m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,007,962 | $5.2m | 0.0% |
| Affinity Asset Advisors, LLC | 1,000,000 | $5.2m | 0.2% |
| GREAT POINT PARTNERS LLC | 951,809 | $4.9m | 0.9% |
| Ikarian Capital, LLC | 935,012 | $4.9m | 0.5% |
| DIMENSIONAL FUND ADVISORS LP | 890,733 | $4.6m | 0.0% |
| 22NW, LP | 820,653 | $4.3m | 4.1% |
| Velan Capital Investment Management LP | 750,000 | $3.9m | 2.4% |