| FMR LLC | 37,429,515 | $130.6m | 0.0% |
| Flagship Pioneering, LLC | 25,001,856 | $87.3m | 5.7% |
| RA CAPITAL MANAGEMENT, L.P. | 18,750,000 | $65.4m | 0.6% |
| BlackRock, Inc. | 16,675,173 | $58.2m | 0.0% |
| STATE STREET CORP | 11,203,134 | $39.1m | 0.0% |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,218,400 | $35.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,375,421 | $29.2m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 5,748,454 | $20.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,677,959 | $16.3m | 0.0% |
| Marex Group Ltd | 3,989,100 | $13.9m | 0.1% |
| MARSHALL WACE, LLP | 2,931,436 | $10.2m | 0.0% |
| Alphabet Inc. | 2,812,500 | $9.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,367,935 | $8.3m | 0.0% |
| Integral Health Asset Management, LLC | 2,000,000 | $7.0m | 0.3% |
| TORONTO DOMINION BANK | 1,972,381 | $6.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,881,689 | $6.6m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,868,718 | $6.5m | 0.0% |
| NORTHERN TRUST CORP | 1,604,084 | $5.6m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,379,181 | $4.8m | 0.0% |
| Woodline Partners LP | 1,317,932 | $4.6m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 1,237,437 | $4.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,231,100 | $4.3m | 0.0% |
| MORGAN STANLEY | 1,139,782 | $4.0m | 0.0% |
| UBS Group AG | 1,061,441 | $3.7m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 963,147 | $3.4m | 0.0% |