| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | $234.3m | 2.0% |
| TRV GP V, LLC | 6,215,591 | $208.2m | 41.8% |
| Driehaus Capital Management LLC | 4,433,058 | $148.5m | 0.9% |
| TRV GP VI, LLC | 4,211,659 | $141.0m | 60.7% |
| SAMSARA BIOCAPITAL, LLC | 3,149,128 | $105.5m | 8.7% |
| GOLDMAN SACHS GROUP INC | 3,062,766 | $102.6m | 0.0% |
| BlackRock, Inc. | 1,932,088 | $64.7m | 0.0% |
| Siren, L.L.C. | 1,900,000 | $63.6m | 1.3% |
| Avoro Capital Advisors LLC | 1,337,500 | $44.8m | 0.4% |
| Jupiter Topco LLC | 1,307,500 | $43.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,221,673 | $40.9m | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 1,167,382 | $39.1m | 0.0% |
| First Light Asset Management, LLC | 963,260 | $32.3m | 2.0% |
| ADAR1 Capital Management, LLC | 940,747 | $31.5m | 1.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 679,163 | $22.8m | 0.0% |
| STATE STREET CORP | 652,630 | $21.9m | 0.0% |
| LOOMIS SAYLES & CO L P | 624,752 | $20.9m | 0.0% |
| Casdin Capital, LLC | 553,268 | $18.5m | 0.9% |
| Catalio Capital Management, LP | 536,152 | $18.0m | 3.4% |
| ALGERT GLOBAL LLC | 397,487 | $13.3m | 0.2% |
| Kalehua Capital Management LLC | 389,088 | $13.0m | 4.2% |
| Balyasny Asset Management L.P. | 350,442 | $11.7m | 0.0% |
| Longaeva Partners L.P. | 298,171 | $10.0m | 0.2% |
| Soleus Capital Management, L.P. | 275,000 | $9.2m | 0.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 230,184 | $7.7m | 0.0% |