| BAKER BROS. ADVISORS LP | 32,786,348 | $477.7m | 2.4% |
| FMR LLC | 10,043,947 | $146.3m | 0.0% |
| STATE STREET CORP | 9,536,796 | $139.0m | 0.0% |
| BlackRock, Inc. | 9,529,041 | $138.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,734,484 | $83.6m | 0.0% |
| UBS Group AG | 5,233,798 | $76.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 5,042,190 | $73.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 4,513,399 | $65.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,893,820 | $56.7m | 0.0% |
| Point72 Asset Management, L.P. | 3,697,803 | $53.9m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,427,263 | $50.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,349,081 | $34.2m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,989,591 | $29.0m | 0.0% |
| Balyasny Asset Management L.P. | 1,904,254 | $27.7m | 0.0% |
| CITADEL ADVISORS LLC | 1,725,716 | $25.1m | 0.0% |
| Aberdeen Group plc | 1,693,626 | $24.7m | 0.0% |
| Squarepoint Ops LLC | 1,590,736 | $23.2m | 0.0% |
| MORGAN STANLEY | 1,450,019 | $21.1m | 0.0% |
| NORGES BANK | 1,382,519 | $20.1m | 0.0% |
| Logos Global Management LP | 1,350,000 | $19.7m | 0.8% |
| Octagon Capital Advisors LP | 1,250,000 | $18.2m | 1.6% |
| D. E. Shaw & Co., Inc. | 1,243,556 | $18.1m | 0.0% |
| Kynam Capital Management, LP | 1,200,000 | $17.5m | 1.0% |
| Pictet Asset Management Holding SA | 1,134,299 | $16.4m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 976,851 | $14.2m | 0.0% |