| Madryn Asset Management, LP | 18,540,488 | $24.1m | 65.3% |
| UBS Group AG | 2,279,099 | $3.0m | 0.0% |
| WEXFORD CAPITAL LP | 2,002,625 | $2.6m | 0.3% |
| FourWorld Capital Management LLC | 1,744,142 | $2.3m | 2.2% |
| Lane Generational LLC | 1,633,372 | $2.1m | 1.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,507,097 | $2.0m | 0.0% |
| MASTERS CAPITAL MANAGEMENT LLC | 1,000,000 | $1.3m | 0.0% |
| AdvisorShares Investments LLC | 742,795 | $965,634 | 0.1% |
| Ikarian Capital, LLC | 701,182 | $911,537 | 0.1% |
| BlackRock, Inc. | 596,622 | $775,608 | 0.0% |
| HighTower Advisors, LLC | 563,741 | $732,863 | 0.0% |
| MARSHALL WACE, LLP | 485,692 | $631,400 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 458,474 | $596,242 | 0.0% |
| CITADEL ADVISORS LLC | 421,903 | $548,474 | 0.0% |
| Dauntless Investment Group, LLC | 369,187 | $479,943 | 0.4% |
| STATE STREET CORP | 290,299 | $377,389 | 0.0% |
| Centiva Capital, LP | 285,913 | $371,687 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 264,734 | $344,154 | 0.0% |
| GOLDMAN SACHS GROUP INC | 264,088 | $343,314 | 0.0% |
| JBF Capital, Inc. | 233,166 | $303,116 | 0.0% |
| XTX Topco Ltd | 220,323 | $286,420 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 199,450 | $259,285 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 189,263 | $246,042 | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,753 | $241,479 | 0.0% |
| JANE STREET GROUP, LLC | 185,250 | $240,825 | 0.0% |