| T. Rowe Price Investment Management, Inc. | 13,432,540 | $93.2m | 0.1% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,122,179 | $56.4m | 0.1% |
| Redmile Group, LLC | 6,892,033 | $47.8m | 3.2% |
| ORBIMED ADVISORS LLC | 6,306,127 | $43.8m | 0.8% |
| Prosight Management, LP | 5,957,877 | $41.3m | 7.1% |
| BlackRock, Inc. | 3,935,810 | $27.3m | 0.0% |
| Frazier Life Sciences Management, L.P. | 3,750,000 | $26.0m | 0.6% |
| NEXTBio Capital Management LP | 3,727,348 | $25.9m | 11.9% |
| Deep Track Capital, LP | 3,706,734 | $25.7m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,207,865 | $22.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,641,076 | $18.3m | 0.0% |
| PINNACLE ASSOCIATES LTD | 1,871,442 | $13.0m | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,767,938 | $12.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,584,756 | $11.0m | 0.0% |
| CLARK ESTATES INC/NY | 1,430,167 | $9.9m | 2.3% |
| Aberdeen Group plc | 1,405,851 | $9.8m | 0.0% |
| Point72 Asset Management, L.P. | 1,170,732 | $8.1m | 0.0% |
| 683 Capital Management, LLC | 1,157,216 | $8.0m | 0.4% |
| STATE STREET CORP | 1,026,394 | $7.1m | 0.0% |
| Boxer Capital Management, LLC | 1,000,000 | $6.9m | 0.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 946,985 | $6.6m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 743,761 | $5.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 593,324 | $4.1m | 0.0% |
| TD Asset Management Inc | 558,876 | $3.9m | 0.0% |
| NORTHERN TRUST CORP | 520,316 | $3.6m | 0.0% |