| DAFNA Capital Management LLC | 13,680,554 | $23.5m | 4.5% |
| BlackRock, Inc. | 4,396,835 | $7.6m | 0.0% |
| Lagoda Investment Management, L.P. | 4,122,600 | $7.1m | 3.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,044,820 | $5.2m | 0.0% |
| Arbiter Partners Capital Management LLC | 2,883,856 | $5.0m | 1.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,895,243 | $3.3m | 0.0% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 1,521,966 | $2.6m | 0.3% |
| Archon Capital Management LLC | 1,226,044 | $2.1m | 0.9% |
| Warberg Asset Management LLC | 1,108,889 | $1.9m | 0.3% |
| STATE STREET CORP | 916,780 | $1.6m | 0.0% |
| AlphaCentric Advisors LLC | 600,000 | $1.0m | 0.9% |
| VANGUARD FIDUCIARY TRUST CO | 589,110 | $1.0m | 0.0% |
| Bank Julius Baer & Co. Ltd, Zurich | 540,530 | $929,710 | 0.0% |
| NORTHERN TRUST CORP | 529,695 | $911,076 | 0.0% |
| Legato Capital Management LLC | 512,907 | $882,200 | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 463,580 | $797,358 | 0.0% |
| Sequoia Financial Advisors, LLC | 381,355 | $655,931 | 0.0% |
| MORGAN STANLEY | 332,107 | $571,226 | 0.0% |
| UBS Group AG | 251,333 | $432,293 | 0.0% |
| Prescott Group Capital Management, L.L.C. | 237,495 | $408,491 | 0.0% |
| GOLDMAN SACHS GROUP INC | 234,971 | $404,151 | 0.0% |
| SEI INVESTMENTS CO | 234,612 | $403,533 | 0.0% |
| Bank of New York Mellon Corp | 211,641 | $364,022 | 0.0% |
| Independent Advisor Alliance | 208,485 | $358,593 | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 196,622 | $338,190 | 0.0% |