| NEA Management Company, LLC | 24,471,264 | $150.7m | 9.5% |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | $108.4m | 6.4% |
| Venrock Adviser, LLC | 14,745,943 | $90.8m | 2.8% |
| Nantahala Capital Management, LLC | 13,953,620 | $86.0m | 1.4% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 13,569,000 | $83.6m | 0.9% |
| BlackRock, Inc. | 12,494,498 | $77.0m | 0.0% |
| TCG Crossover Management, LLC | 12,362,205 | $76.2m | 1.8% |
| Frazier Life Sciences Management, L.P. | 9,720,852 | $59.9m | 1.3% |
| Polar Capital Holdings Plc | 9,541,786 | $58.8m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 7,932,545 | $48.9m | 0.0% |
| STATE STREET CORP | 6,553,348 | $40.4m | 0.0% |
| MARSHALL WACE, LLP | 6,256,989 | $38.5m | 0.0% |
| RTW INVESTMENTS, LP | 5,952,380 | $36.7m | 0.3% |
| Woodline Partners LP | 4,245,119 | $26.1m | 0.1% |
| ORBIMED ADVISORS LLC | 3,959,900 | $24.4m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,872,133 | $23.9m | 0.0% |
| Spruce Street Capital LP | 3,452,576 | $21.3m | 4.2% |
| Rosalind Advisors, Inc. | 3,178,121 | $19.6m | 7.3% |
| EMERALD ADVISERS, LLC | 3,148,439 | $19.4m | 0.5% |
| Pictet Asset Management Holding SA | 2,763,055 | $17.0m | 0.0% |
| Vestal Point Capital, LP | 2,720,000 | $16.8m | 0.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,694,812 | $16.6m | 0.0% |
| D. E. Shaw & Co., Inc. | 2,514,998 | $15.5m | 0.0% |
| Affinity Asset Advisors, LLC | 2,512,153 | $15.5m | 0.7% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,375,999 | $14.6m | 0.5% |