| Nantahala Capital Management, LLC | 11,788,228 | $8.8m | 0.1% |
| Essex Woodlands Management, Inc. | 7,714,709 | $5.8m | 2.3% |
| Stonepine Capital Management, LLC | 2,662,427 | $2.0m | 0.5% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,137,201 | $1.6m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,568,218 | $1.2m | 0.0% |
| DAFNA Capital Management LLC | 1,441,029 | $1.1m | 0.2% |
| PERKINS CAPITAL MANAGEMENT INC | 1,375,042 | $1.0m | 0.8% |
| Sio Capital Management, LLC | 636,300 | $477,225 | 0.1% |
| WealthTrust Axiom LLC | 457,734 | $343,300 | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 389,223 | $291,952 | 0.0% |
| BlackRock, Inc. | 374,516 | $280,887 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 213,138 | $159,854 | 0.0% |
| UP STRATEGIC WEALTH INVESTMENT ADVISORS LLC | 99,888 | $91,398 | 0.1% |
| Embree Financial Group | 90,906 | $68,180 | 0.0% |
| NORTHERN TRUST CORP | 74,790 | $56,093 | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 67,700 | $50,775 | 0.0% |
| STATE STREET CORP | 63,383 | $47,537 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 58,100 | $43,575 | 0.0% |
| PNC Financial Services Group, Inc. | 53,612 | $40,209 | 0.0% |
| Destiny Wealth Partners, LLC | 52,500 | $38,320 | 0.0% |
| Ducere Wealth Management LLC | 51,000 | $38,250 | 0.0% |
| JANE STREET GROUP, LLC | 49,245 | $36,933 | 0.0% |
| UBS Group AG | 33,466 | $25,100 | 0.0% |
| XTX Topco Ltd | 29,558 | $22,169 | 0.0% |
| TD Waterhouse Canada Inc. | 23,000 | $16,560 | 0.0% |