| RTW INVESTMENTS, LP | 13,900,620 | $434.5m | 3.7% |
| BlackRock, Inc. | 12,438,444 | $388.8m | 0.0% |
| FMR LLC | 12,333,339 | $385.5m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 12,277,000 | $383.8m | 1.8% |
| Boxer Capital Management, LLC | 10,876,219 | $340.0m | 25.6% |
| GOLDMAN SACHS GROUP INC | 9,980,620 | $312.0m | 0.0% |
| TCG Crossover Management, LLC | 9,081,201 | $283.9m | 6.8% |
| Paradigm Biocapital Advisors LP | 6,357,523 | $198.7m | 3.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,348,827 | $198.5m | 0.0% |
| Siren, L.L.C. | 6,179,364 | $193.2m | 3.9% |
| STATE STREET CORP | 5,979,806 | $186.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,957,348 | $186.2m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,600,000 | $175.1m | 0.2% |
| Jupiter Topco LLC | 5,056,352 | $158.0m | 0.1% |
| Deep Track Capital, LP | 4,200,000 | $131.3m | 1.9% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,190,611 | $131.0m | 1.4% |
| Woodline Partners LP | 4,000,567 | $125.1m | 0.4% |
| TRV GP IV, LLC | 6,374,574 | $120.2m | 47.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,742,791 | $117.0m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 3,377,000 | $105.6m | 1.6% |
| Seven Fleet Capital Management LP | 3,228,144 | $95.7m | 15.8% |
| Logos Global Management LP | 2,850,000 | $89.1m | 3.8% |
| Caligan Partners LP | 2,500,103 | $78.2m | 3.7% |
| Holocene Advisors, LP | 2,410,939 | $75.4m | 0.2% |
| Commodore Capital LP | 2,250,000 | $70.3m | 4.2% |