| BAKER BROS. ADVISORS LP | 5,072,730 | $37.3m | 0.2% |
| 5AM Venture Management, LLC | 4,056,379 | $29.9m | 10.4% |
| BlackRock, Inc. | 2,583,333 | $19.0m | 0.0% |
| Merck & Co., Inc. | 1,739,768 | $12.8m | 2.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,269,634 | $9.3m | 0.0% |
| MPM BIOIMPACT LLC | 1,253,053 | $9.2m | 0.6% |
| TCG Crossover Management, LLC | 1,060,230 | $7.8m | 0.2% |
| WELLINGTON MANAGEMENT GROUP LLP | 954,419 | $7.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 763,959 | $5.6m | 0.0% |
| StepStone Group LP | 761,277 | $5.6m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 717,430 | $5.3m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 699,537 | $5.1m | 0.0% |
| Nantahala Capital Management, LLC | 601,150 | $4.4m | 0.1% |
| STATE STREET CORP | 596,677 | $4.4m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 542,316 | $4.0m | 0.0% |
| JPMORGAN CHASE & CO | 496,457 | $3.8m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 400,862 | $2.9m | 0.0% |
| CITADEL ADVISORS LLC | 394,323 | $2.9m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 376,136 | $2.8m | 0.0% |
| NORTHERN TRUST CORP | 309,942 | $2.3m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 303,459 | $2.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 254,130 | $1.9m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 197,136 | $1.5m | 0.0% |
| Longaeva Partners L.P. | 195,237 | $1.4m | 0.0% |
| MORGAN STANLEY | 191,650 | $1.4m | 0.0% |