| BlackRock, Inc. | 5,747,760 | $246.6m | 0.0% |
| Avoro Capital Advisors LLC | 5,723,888 | $245.6m | 2.2% |
| STATE STREET CORP | 4,148,786 | $178.0m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,012,936 | $172.2m | 0.0% |
| Deep Track Capital, LP | 4,000,000 | $171.6m | 2.5% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,916,400 | $168.1m | 1.8% |
| Kynam Capital Management, LP | 2,890,059 | $124.0m | 6.9% |
| MORGAN STANLEY | 2,799,459 | $120.1m | 0.0% |
| Sofinnova Investments, Inc. | 2,793,987 | $119.9m | 6.2% |
| FMR LLC | 2,774,070 | $119.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,755,413 | $118.2m | 0.0% |
| Eversept Partners, LP | 2,212,770 | $94.9m | 4.9% |
| Logos Global Management LP | 2,200,000 | $94.4m | 4.1% |
| Integral Health Asset Management, LLC | 1,750,000 | $75.1m | 3.0% |
| Bellevue Group AG | 1,710,808 | $73.4m | 1.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,692,442 | $72.6m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 1,591,043 | $64.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,380,835 | $59.3m | 0.0% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,295,405 | $55.6m | 0.5% |
| Pictet Asset Management Holding SA | 1,249,414 | $53.6m | 0.1% |
| DEUTSCHE BANK AG\ | 1,102,106 | $47.3m | 0.0% |
| Qube Research & Technologies Ltd | 1,083,179 | $46.5m | 0.0% |
| Woodline Partners LP | 1,001,037 | $43.0m | 0.1% |
| AMERICAN CENTURY COMPANIES INC | 866,243 | $37.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 642,873 | $27.6m | 0.0% |