| TCG Crossover Management, LLC | 5,673,078 | $104.4m | 2.5% |
| FMR LLC | 4,932,149 | $90.8m | 0.0% |
| FCPM III SERVICES B.V. | 4,117,354 | $75.8m | 10.1% |
| BlackRock, Inc. | 3,468,107 | $63.8m | 0.0% |
| Venrock Adviser, LLC | 3,041,719 | $56.0m | 1.7% |
| STATE STREET CORP | 2,616,336 | $48.2m | 0.0% |
| Frazier Life Sciences Management, L.P. | 2,543,939 | $46.8m | 1.0% |
| RA CAPITAL MANAGEMENT, L.P. | 2,402,095 | $44.2m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,084,328 | $38.4m | 0.0% |
| Caligan Partners LP | 1,925,066 | $35.4m | 1.7% |
| Paradigm Biocapital Advisors LP | 1,750,000 | $32.2m | 0.6% |
| GREAT POINT PARTNERS LLC | 1,700,000 | $31.3m | 5.9% |
| Nantahala Capital Management, LLC | 1,690,000 | $31.1m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,062,469 | $19.6m | 0.0% |
| NEXTBio Capital Management LP | 889,164 | $16.4m | 7.5% |
| ADAR1 Capital Management, LLC | 680,626 | $12.5m | 0.6% |
| Logos Global Management LP | 650,000 | $12.0m | 0.5% |
| Rosalind Advisors, Inc. | 648,600 | $11.9m | 4.4% |
| NAN FUNG TRINITY (HK) LTD | 646,550 | $11.9m | 1.2% |
| BRAIDWELL LP | 573,104 | $10.6m | 0.4% |
| BOOTHBAY FUND MANAGEMENT, LLC | 558,702 | $10.3m | 0.1% |
| UBS Group AG | 493,278 | $9.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 428,067 | $7.9m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 416,417 | $7.7m | 1.0% |
| Woodline Partners LP | 379,723 | $7.0m | 0.0% |