| FMR LLC | 16,604,740 | $305.0m | 0.0% |
| BlackRock, Inc. | 8,551,488 | $157.1m | 0.0% |
| Bellevue Group AG | 6,731,909 | $123.7m | 2.6% |
| Paradigm Biocapital Advisors LP | 6,723,788 | $123.5m | 2.3% |
| Kynam Capital Management, LP | 6,453,877 | $118.6m | 6.6% |
| STATE STREET CORP | 6,124,976 | $112.5m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,748,410 | $105.6m | 0.0% |
| Fairmount Funds Management LLC | 5,090,928 | $93.5m | 6.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,576,860 | $84.1m | 0.0% |
| Deep Track Capital, LP | 3,592,740 | $66.0m | 1.0% |
| Venrock Adviser, LLC | 3,257,917 | $59.8m | 1.8% |
| WELLINGTON MANAGEMENT GROUP LLP | 3,128,362 | $57.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,752,827 | $50.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,501,869 | $46.0m | 0.0% |
| Avoro Capital Advisors LLC | 2,500,000 | $45.9m | 0.4% |
| BAKER BROS. ADVISORS LP | 2,383,025 | $43.8m | 0.2% |
| Point72 Asset Management, L.P. | 2,343,208 | $43.0m | 0.0% |
| Caligan Partners LP | 2,193,981 | $40.3m | 1.9% |
| NOVO HOLDINGS A/S | 2,135,000 | $39.2m | 2.3% |
| TANG CAPITAL MANAGEMENT LLC | 1,792,626 | $32.9m | 1.5% |
| Fisher Asset Management, LLC | 1,750,850 | $32.2m | 0.0% |
| Candriam S.C.A. | 1,707,698 | $31.3m | 0.1% |
| GOLDMAN SACHS GROUP INC | 1,691,304 | $31.1m | 0.0% |
| First Turn Management, LLC | 1,670,000 | $30.7m | 3.3% |
| DIMENSIONAL FUND ADVISORS LP | 1,611,521 | $29.6m | 0.0% |