| BlackRock, Inc. | 9,192,447 | $35.1m | 0.0% |
| Nantahala Capital Management, LLC | 7,169,640 | $27.4m | 0.5% |
| ARMISTICE CAPITAL, LLC | 7,024,000 | $26.8m | 0.3% |
| RTW INVESTMENTS, LP | 6,635,793 | $25.3m | 0.2% |
| Deep Track Capital, LP | 5,740,850 | $21.9m | 0.3% |
| STATE STREET CORP | 5,133,859 | $19.6m | 0.0% |
| Rosalind Advisors, Inc. | 3,986,509 | $15.2m | 5.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,851,508 | $14.7m | 0.0% |
| Stonepine Capital Management, LLC | 3,349,627 | $12.8m | 3.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,266,870 | $12.5m | 0.0% |
| Foresite Capital Management VI LLC | 3,146,631 | $12.0m | 1.9% |
| GOLDMAN SACHS GROUP INC | 2,721,178 | $10.4m | 0.0% |
| BAKER BROS. ADVISORS LP | 2,499,338 | $9.5m | 0.0% |
| Alyeska Investment Group, L.P. | 2,289,625 | $8.7m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,078,003 | $7.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,074,145 | $7.9m | 0.0% |
| AIGH Capital Management LLC | 1,927,000 | $7.4m | 0.5% |
| Opaleye Management Inc. | 1,800,000 | $6.9m | 0.6% |
| Balyasny Asset Management L.P. | 1,686,575 | $6.4m | 0.0% |
| Qube Research & Technologies Ltd | 1,628,488 | $6.2m | 0.0% |
| ACORN CAPITAL ADVISORS, LLC | 1,469,153 | $5.6m | 1.5% |
| NEXTBio Capital Management LP | 1,306,800 | $5.0m | 2.3% |
| FRANKLIN RESOURCES INC | 1,105,021 | $4.2m | 0.0% |
| Pinnacle Financial Partners, Inc. | 1,086,440 | $4.2m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 934,565 | $3.6m | 0.0% |